Pharmacologist Salary in USA

As the ASSOCIATE/DIRECTOR, COMPUTATIONAL CHEMISTRY, you will work as part of a multi-disciplinary team of Medicinal Chemists, Computational Chemists, Structural biologists, Pharmacologists and Biologists to provide Computational expertise to advance drug discovery projects.You will contribute to drug discovery efforts across various modalities including small molecules, bifunctional degraders, peptides, RNA/oligonucleotides, and biologics.You will implement and execute innovative computational methodologies and tools such as AI approaches to support drug discovery efforts.Responsibilities:Responsible for visibility and representation of Computational Chemistry Accomplishments to the executive team.Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success.Provide important technical knowledge and input to project teams to drive decision making in drug discovery projects.Manage and mentor a Strong team of Computational Chemists to high productivity levelsRequirements:PhD degree in a Computational Chemistry with 10+ years experience in Pharma/Biotech10+ years of Industry experience including 2+ years in leadership roles and mentoring direct reports is requiredStrong expertise in a variety of computational tools and methodologies including Docking, Virtual screening, Molecular dynamics, Free energy perturbation, Homology modeling, Quantum mechanics, Pharmacophore elucidation, Data mining, Cheminformatics, Clustering, Similarity & Diversity analysis.Strong Impact on progressing Discovery Projects from Hits to Clinical LeadsStrong knowledge & experience in using a variety of tools for Hit IDProvide project teams with computational strategies to inform, influence, and prioritize compound designs for potency/selectivity and improve ADME/Tox endpoints.Contribute to the design, development and deployment of AI platforms to impact drug discovery.Identify and implement novel computational chemistry algorithms, technologies, and workflows.Strong Proficiency with state of the art Computational chemistry software.Proficiency in scientific scripting and programming languages

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com.This position is based in Northbrook, Illinois. Remote work from certain states may be permitted in accordance with Astellas' Responsible Flexibility Guidelines. Candidates interested in remote work are encouraged to apply.Purpose and Scope:The Director, Global Clinical Pharmacology will have ultimate responsibility and accountability for clinical pharmacology from first-in human through approval, including post-marketing activities for assigned projects.The Director will be responsible for therapeutic optimization and individualization (right dose for right patient) by applying state-of-the-art scientific principles and quantitative framework (e.g. MIDD) to evaluate exposure-response relationships based on knowledge of drug disposition, pharmacology, disease biology, patient population, competitive landscape, background therapy, patient variability in PK and responses, formulation effects, impact of immunogenicity.Essential Job Responsibilities:Representing the department and providing subject matter expertise on cross-functional project teams starting with candidate nomination (pre-initiation of GLP tox) through approval and post marketingLeading cross-functional sub-teams necessary by phase of development to achieve Clinical Pharmacology goalsProviding effective oversight of clinical pharmacology aspects of clinical trials (including study design, interpretation and communication of results)Participating in cross-functional discussions and collaborating with individuals across disciplines; mentoring junior membersAuthoring/reviewing clinical protocols, analysis plans, study reports and regulatory submissionsDeveloping high quality clinical pharmacology plans and content for global regulatory submissions, including INDs, IBs, NDAs, MAAs, diversity and pediatric plansPresentation of clinical pharmacology aspects of the global clinical development program at internal and external meetings. For example: meetings with health authorities, congresses, investigator meetings Quantitative Dimensions:Be involved in the design, analysis, and reporting at least 3 to 10 clinical studies per yearAs a global clinical pharmacology lead (GCPL), provide the scientific lead for a cross-functional team of 15 - 25 peopleSupervise 1-3 junior GCPLs.Responsibilities may directly impact on strategy and efficiency of clinical development of compounds.Has responsibilities for contributing to the overall annual budgeting and assessment of resources for assigned projects for executing clinical pharmacology strategy from FIM to registrationHas responsibilities that directly impacts on strategy and efficiency of clinical development of compounds, especially in the early and late phases.Organizational Context:Reports to Clinical Pharmacology Senior Director or higher, within Early DevelopmentMay have direct reporting global or regional clinical pharmacologistsMay have functional management of scientistsLocation(s)Northbrook, ILQualifications RequiredPhD or PharmD with fellowship in clinical pharmacologyAt least 7 years post-graduate experience, in pharmaceutical industry.Thorough knowledge of current and emerging scientific standards and global regulatory requirements including familiarity with relevant guidanceWorking knowledge of assigned therapeutic area, biomarkers, bioanalytical methods, immunogenicityHave thorough understanding of early development, clinical methodologies, POC, and clinical endpoints within a specific therapeutic areaKnowledge of biologics drug developmentExcellent written and oral communication skills and ability to convey complex technical information clearlyExpert knowledge of clinical pharmacology in drug development, with a strong scientific and strategic mindset and experience with clinical dose setting (including first in human dose setting) and pharmacokinetic/pharmacodynamic relationshipsExperience integrating modeling and simulation activities (i.e., population PK, exposure-response and physiologically based PK) to support the clinical pharmacology planAdaptability and curiosity to learn about new modalities and apply core clinical pharmacology principles to novel therapeuticsCuriosity and drive to ask questions, learn and keep abreast of literatureConfidence and ability to present to and influence senior leadersAbility to critically analyze problems and provide creative/innovative solutionsAbility and confidence to work independentlyBenefits:Medical, Dental and Vision InsuranceGenerous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks401(k) match and annual company contributionCompany paid life insuranceAnnual Corporate Bonus and Quarterly Sales Incentive for eligible positionsLong Term Incentive Plan for eligible positionsReferral bonus program

Senior Director, Clinical Pharmacology & Quantitative Pharmacology (CPQP) - ADCIntroduction to role:Are you ready to make a meaningful impact on patients' lives? We are seeking a Senior Director for our Clinical Pharmacology & Quantitative Pharmacology (CPQP) team within the Biopharmaceuticals R&D division. This role is a unique blend of line management and project accountabilities, with the opportunity to lead scientific, strategic, and improvement initiatives at various levels. You will be responsible for leading a dynamic team of Clinical Pharmacologists and Clinical Pharmacometricians, ensuring consistent and valued CPQP contributions across the portfolio.Accountabilities:As a Senior Director, you will lead a team delivering quality clinical pharmacology input to projects from pre-CDID to life-cycle management (LCM). You will be accountable for resource management, providing flexible, competent and responsive service according to business needs. You will also act as a delegate for the TA Head at functional LT meetings, Clin Pharm review Board, governance, and other TA interactions, as necessary. Your role will involve developing a culture supportive of MIDD approaches across the TA influencing key partners, stakeholders and regulators of its value and application. Essential Skills/Experience:- PhD degree or equivalent (M.Sc./Pharm.D.) with relevant experience required,- Demonstrated broad translational and clinical development experience exemplified by a minimum of 10 years international drug development or equivalent experience in large and small molecules (early and late clinical)- Can develop people, drives performance, holds self and others accountable- Record of building successful internal/external partnership and collaboration relationships, demonstrating cultural sensitivity and awareness- Experience of leading teams- Strong leadership capabilities including influencing skills- Experience in mentoring and developing others - Conceptual, analytical and strategic thinking- International scientific reputation gained from scientific publishing in the field of quantitative clinical pharmacology- Demonstrated ability to identify, develop and execute strategic CPQP activities - Relevant TA disease domain knowledge- Relevant regulatory experience (written/oral)- A demonstrated knowledge of regulatory, compliance, processes, standards and issues specific to CPQPDesirable Skills/Experience:- Experience in several organisations- Experience in discovery and development of ADCsAt AstraZeneca, we follow the science to explore and innovate. We are driven by our desire to understand and reveal new insights. We are free from fear of failure, free to ask the right questions, make bold decisions, and dig deep into the biology of complex disease. We take inspiration from within our BioPharmaceutical heritage, as well as beyond, exploring what we can take and apply. We are always listening and learning from people who live with the diseases our medicines treat. It enables us to better understand their needs and, ultimately, diagnose and design the right treatments to impact patients' lives.Are you ready to push the boundaries of science to deliver life-changing medicines? If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be.Apply today!AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Are you an expert within Safety Pharmacology with extensive knowledge in designing and interpreting high quality studies, translating scientific findings into applicable information in a drug development environment? Be part of a dedicated Research & Development team. Fuelled by our commitment to help more patients, strengthen our pipeline and grow our area.To help deliver our growing portfolio, we are currently seeking an experienced Safety Pharmacologist to join the Safety & Mechanistic Pharmacology team at AstraZeneca as a Director, Safety and Mechanistic Pharmacology.The Regulatory Toxicology and Safety Pharmacology team sits within CPSS and plays a central role in progressing a rich and diverse pipeline comprising many different modalities across all of our therapeutic areas. We work collaboratively to deliver safety science from early discovery through clinical development, with emphasis on the science and studies required to enable the clinical development of new medicines. Clinical Pharmacology & Safety Sciences (CPSS) is a multi-faceted department which underpins AstraZeneca's Biopharmaceutical and Oncology Portfolio from target selection through to Life-cycle management.What you will do:In this role you will apply your extensive drug discovery expertise to support the progression of a progression of a broad portfolio of drug projects. You'll be responsible for authoring Safety Pharmacology sections of submission documents, engaging with and responding to Health Authority questions and contributing to the labelling of new products. Earlier in the drug discovery pipeline, you will be designing and interpreting safety pharmacology studies enabling first time in human submissions as well as investigative work at all stages. This will involve close collaboration with a wide range of experts in a highly matrixed environment across the development chain, for multiple project safety teams in parallel. You'll be working with many different modalities beyond classical biopharmaceuticals, so you'll need to be creative and work in areas where there are no pre-defined solutions, utilising the best capabilities within and outside AstraZeneca.In this role you will use your extensive drug discovery expertise to set the overall Safety Pharmacology strategy for the Cardiovascular, Renal and Metabolic (CVRM) portfolio, and applying this to enable the progression of a broad range of drug projects. To achieve this you'll work closely with multiple project safety teams, collaborating with a wide range of experts in a highly matrixed environment across the development chain. You'll be responsible for designing and interpreting safety pharmacology studies enabling first time in human submissions as well as investigative work at all stages. You'll be working with many different modalities beyond classical biopharmaceuticals, so you'll need to be creative and work in areas where there are no pre-defined solutions, utilising the best capabilities within and outside AstraZeneca.Your main tasks will include:Design and interpret fit for purpose safety pharmacology packages and guide projects with tangible, quantitative risk assessments that underpin science-driven decisions.Develop patient-centric safety pharmacology risk assessment strategies applicable to novel therapeutic modalities, where conventional approaches may not be appropriate or possible.Author non-clinical safety pharmacology sections of regulatory submission documents and engage with regulatory authorities to secure approval of IMPD/IND and MAA/NDA submissions.Extend the Safety Pharmacology beyond the boundaries defined by ICH S7A and S7B and shape the discipline externally with publications, collaborations and involvement in consortia.Essential in the role:Extensive experience in pharmaceutical development, with a PhD (or equivalent experience) in pharmacology, toxicology, pathology or a related Natural Science field.Experience of Safety Pharmacology in drug discovery and development, with exposure to non-clinical safety assessment in a project setting.Experience with nonclinical regulatory submissions and health authority interactionsDemonstrable expertise in the design and interpretation of in vitro and in vivo studies, translating scientific findings into applicable information in a drug development environment.Familiarity with pharmacokinetic-pharmacodynamic and systems pharmacology approaches.Validated ability to run a large portfolio of projects including prioritize activities in a matrix environment.Understanding of the external factors that shape the scientific and regulatory landscapes relevant to Safety Pharmacology.Proven strong scientific track record and problem-solving capabilities.We also believe that the successful candidate should have high ability to communicate and present your work in a natural and clear way and enjoy working across multi-disciplinary teams with efficiency. Desirable in the role:In depth knowledge of cardiac function, ECG and imaging modalities.Diplomat of Safety Pharmacology, DABT or ERT accreditation.AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Company Summary:Quotient Therapeutics, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.Quotient Therapeutics, Inc. was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Seres Therapeutics (NASDAQ: MCRB), Sana Biotechnology (SANA), Axcella Health (AXLA), Indigo Agriculture, Generate Biomedicines, and Tessera Therapeutics.Position Summary:We are seeking a visionary Head of Biology to develop and advance an industry first pipeline informed by somatic genomics. The position has the unique opportunity to create a vision and implement the strategy that will make a major impact. The Head of Biology will lead cross-validation and prioritization of drug targets, leveraging data-science, functional genomics, biochemistry, mechanistic biology, and disease models. The successful candidate is a confident leader with extensive prior success in drug discovery, preferably in multiple therapeutic areas such as immunology, oncology, metabolic diseases, CNS, etc. Experience with leading and working with computational biology and statistical biology teams to use multi-omics data to inform biology is preferred. The successful candidate will have a track record of accomplishments in drug discovery as well as demonstrated high impact research in academia or industry. S(he) must exhibit excellent leadership, project management, and strong collaboration and communication skills. S(he) should be ready to champion new ideas in a very dynamic and innovative environment.Responsibilities:Direct the execution of multiple early drug discovery programs, including setting scientific direction, development of program timelines, monitoring of key milestones and decision points, and managing scientific teamEvaluate, triage and cross-validate targets discovered via Quotient's somatic genomics platform, including functional genomics, mechanistic biology, biochemistry, and disease modelsOversee the development ofin vitro and in vivo pre-clinical models across multiple therapeutic areasWork closely with Quotient leadership, defining departmental vision and contributing to cross-company activities and decisions with thoughtful and collaborative engagementRecruit, retain and develop a growing team of biologists and pharmacologistsMaintain close collaboration with data-science, somatic genomics platform, and drug discovery teamsPerform research and development in collaboration with other functions in projects pertaining to a range of potential indicationsKey Qualifications:Ph.D. in biology or related discipline with 10+ years of relevant post-Ph.D. experience with an excellent track record of interrogating disease mechanisms and pathwaysBreadth of therapeutic area expertise and exposure to multiple therapeutic modalities, including small molecules and biologicsWell-versed in target discovery via human geneticsExperience in high-throughput arrayed and/or pooled reverse genetic screens in human cellsTrack record of selecting targets and contributing to successful drug programsAbility to organize and communicate complex data sets in a clear and concise manner to key stakeholders from diverse backgroundsPrior experience working with or leading collaborations with external academic, biotechnology, and contract research organizationsLocation: Cambridge, MAAbout FlagshipFlagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The ICOM Biomedical Sciences Department is searching for a full-time, 12-month non-tenured pharmacologist responsible for the education of osteopathic medical students. The primary responsibilities include providing pharmacology instruction for medical students across a two-year preclinical curriculum; working in collaboration with the Department Chair and colleagues; remaining current in professional areas of interest and participating in professional societies and scholarly activities, participating in all assigned, required, and other related professional services and activities in the college.ResponsibilitiesTeaching Pharmacology to osteopathic medical students using diverse teaching methods, including traditional lectures, active learning, small group, and other creative methods of instruction. Teach in any assigned courses or act as a course director, if assigned. Responsibilities include preparing teaching materials for class sessions; conferring with students on course materials; and reviewing written examinations and assignments. Participating in courses/lectures/workshops to meet the curricular needs of the department to include: course structure and content, written course materials, course assessments, course evaluations and course faculty evaluations. Working closely with other faculty to develop and implement innovative and interactive presentations of the curriculum, continual improvement of teaching through appropriate professional development and peer reviewAdvising and mentoring medical students as they move through their educational journey. Student advising to include time spent meeting with students regarding academic, curricular and career matters. Participation in student mentoring in preparation for examinations including licensing board exams and residency matchingServing the academic mission of the College through service on strategic institutional committees, as assigned, and through extramural service in local and national professional communities. Participating in prospective student interviews. Use academic and professional expertise to serve your profession and the communityAdvancing scholarly work, which may include: medical education research, independent scientific research, and clinical or translational research. Supervision of student participation in departmental research endeavors. Maintaining professional literacy in their academic fieldRepresenting ICOM in a positive and productive manner in areas assigned by the Department Chair and/or the Dean. The faculty member will possess excellent oral and written communication skills. Exchanges non-routine information using tactFamiliarity and adherence to ICOM's bylaws, rules, regulations, administrative and academic practices, policies and procedures as set forth in documents such as the Employee Handbook, College Catalog, ICOM's Code of Ethical Conduct, and AOA's Code of EthicsParticipating in and successfully completing all ICOM required training including, but not limited to discrimination/harassment, safety, and code of conductPerforming other job related duties and special projects as assignedSUPERVISORY RESPONSIBILITIES: Student workers.ICOM is unable to sponsor employment visas at this time.RequirementsMiniumum Qualifications:Terminal degree (PhD, PharmD, or equivalent) with strong expertise in pharmacology or closely related fieldExcellent educational skills, including evidence of substantial teaching experience in higher education, medical education, or other health sciences in an academic settingEvidence of a growth mindset, as demonstrated by the applicant's response to constructive feedback from colleagues and studentsEvidence of being a dynamic team player who values collaboration, collegiality, mutual support, and team cohesionCommitment to delivering high-quality, innovative pharmacology education to future physiciansPreferred Qualifications:Interest and experience in pharmacological teaching in the areas including, but not limited to: reproductive health, infectious disease, cardiology, or gastrointestinal pharmacology in a medical school settingMinimum of two years teaching experience in an osteopathic medical education setting, or a minimum for four years teaching in another health sciences academic settingExperience using innovative teaching methods, including team-based learning, 'flipped classroom', problem-based learning, distance learning, interactive large group presentation, audience response systems, etcKnowledge of instructional technologies and familiarity with Learning Management SystemsExperience with instructional design and curriculum mappingExperience in educational theory, evaluation, and learning assessmentProficiency in medical exam item writing (COMLEX-style and/or USMLE)Track record of scholarly activities (publications, presentations, grantsmanship, etc.)Evidence of service contribution at an academic institution (e.g., committee service, task force participation, applicant interviewing, etc.)Experience in academic advising and mentoring of medical students through all four years of medical school and through the residency match processBenefitsHealth Care Plan (Medical, Dental & Vision)Retirement PlanLife Insurance (Basic, Voluntary & AD&D)Paid Time Off (Vacation, Sick, Holidays, Winter Break)Family LeaveShort Term & Long Term DisabilityTuition Reimbursement